This was a delightfully high-signal roundup, the kind that makes the internet feel like it’s still good for something. A few threads really clicked for me:
1. The Holoclara / “roundworm biology → therapeutics” bit is exactly the kind of translational humility I love: evolution has been running randomized experiments for millions of years, and “parasite-host détente” is basically immunology’s weirdest R&D lab. Your gila monster → GLP-1 analogy lands. 
2. YearMap is such a practical “small tool, big relief” idea. Anything that reduces cognitive load around calendars (especially with kids + travel) is a real health intervention in disguise. I’m very pro “analog clarity, digital convenience.” 
3. The Lp(a) mail-in test callout is also timely, not because everyone needs to become a self-directed preventive cardiologist, but because Lp(a) is one of those inherited risks that’s easy to miss until it isn’t. Your line about primary care being bored/befuddled is… unfortunately relatable. 
4. And the Moerman ethnobotany database mention is a perfect reminder that “modern” medicine is often catching up to patterned human observation, and that making knowledge searchable and usable is its own form of scientific contribution. 
There’s a real hunger right now for people who can bridge biology + meaning + culture without sliding into either cynicism or woo.
Hi David. Always appreciate your insights and the sharing of information and reads that are in your attention. Would be great to get your calendar tool. I like the analog digital solution
I really like this format David! And going founder mode on cancer is really of interest! Looking forward to catching up with you soon. Absolutely a great read for my morning!
This was a delightfully high-signal roundup, the kind that makes the internet feel like it’s still good for something. A few threads really clicked for me:
1. The Holoclara / “roundworm biology → therapeutics” bit is exactly the kind of translational humility I love: evolution has been running randomized experiments for millions of years, and “parasite-host détente” is basically immunology’s weirdest R&D lab. Your gila monster → GLP-1 analogy lands. 
2. YearMap is such a practical “small tool, big relief” idea. Anything that reduces cognitive load around calendars (especially with kids + travel) is a real health intervention in disguise. I’m very pro “analog clarity, digital convenience.” 
3. The Lp(a) mail-in test callout is also timely, not because everyone needs to become a self-directed preventive cardiologist, but because Lp(a) is one of those inherited risks that’s easy to miss until it isn’t. Your line about primary care being bored/befuddled is… unfortunately relatable. 
4. And the Moerman ethnobotany database mention is a perfect reminder that “modern” medicine is often catching up to patterned human observation, and that making knowledge searchable and usable is its own form of scientific contribution. 
There’s a real hunger right now for people who can bridge biology + meaning + culture without sliding into either cynicism or woo.
Glad you enjoyed it - thanks for your feedback
You do a nice job on your newsletter. Pls send YearPlan.
Thanks
Ron Pulvermacher
Hi David. Always appreciate your insights and the sharing of information and reads that are in your attention. Would be great to get your calendar tool. I like the analog digital solution
I really like this format David! And going founder mode on cancer is really of interest! Looking forward to catching up with you soon. Absolutely a great read for my morning!